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Animal-based studies have shown that the muscles of untrained rats take up as much creatine as the muscles of trained rats,but the ANABOLIC effects of creatine are only obvious in trained rats. So if creatine can reduce the effects of fatigue from exercise on the CNS,this might explain a key factor missing from human studies: the role of the CNS in improving recovery following exercise. There are multiple theories for how the CNS can improve recovery in response to training. There are even studies showing that creatine may reduce pain at the joints by increasing levels of blood capillaries, which are critical for tissue repair following exercise. The question that I can't answer until I do some controlled trials in humans is why creatine should improve recovery. In a study published last year, ten untrained subjects undertook 10 weeks of exercise at 60% of maximal oxygen uptake. When the subjects were challenged with a graded exercise protocol with the onset of exhaustion, all 10 subjects improved their oxygen uptake to the same value following a 3-week period of recovery. One subject was given no creatine, while the other three experienced a decline in their lactate test results. However, when the subjects were given creatine during recovery, only the third subject improved their lactate test results. That's probably due to a reduction in the size of the blood vessel, which can cause increased capillary permeability. As we have stated many times, creatine is an ion channel blocker. However, it can improve the efficiency of ATP transport across the blood–and oxygen–flux membranes by reducing the size of the ATP-motive force between the cell membranes. If that effect is seen in vivo, it could contribute to a better recovery following exercise. So we have something to go on now that we haven't really explored yet: whether a higher concentration of creatine will improve recovery after long enough periods of recovery. Until we can figure that out, though, we will probably have to wait until someone comes out with a clinical study in which a high dose of creatine is used during exercise to see if an improvement is seen. Related Article: